The correlation TNF-α gene promoter region -238G, -308G, -857, and -1031 polymorphism with psoriasis vulgaris
نویسندگان
چکیده
Background: Psoriasis vulgaris is a recurrent chronic skin disorder signed by hyperproliferation and epidermal inflammation. One of the etiology psoriasis genetic factors related to polymorphism as disease susceptibility markers. This study was aimed analyze correlation TNF-α gene promoter region with vulgaris. Methods: An analytical observational cross-sectional design identify TNF-region polymorphisms vulgaris. included 45 patients non-psoriasis from April October 2016 at Immuno-dermatology Polyclinic Dermatology Venereology/Haji Adam Malik Hospital, Medan. We isolated DNA blood sample then ran into PCR process specific primers. results were examined electrophoresis 2% agarose. Chi-Square test used hypothesis relationship between significance P <0.05. Result: Analysis found significant in -308G (p=0,001) 1031 (p=0,002) loci.Conclusion: -1031 more frequent case group, commonly control group. Both them significantly correlated
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ژورنال
عنوان ژورنال: Bali Medical Journal
سال: 2021
ISSN: ['2089-1180', '2302-2914']
DOI: https://doi.org/10.15562/bmj.v10i1.2328